Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression
نویسندگان
چکیده
منابع مشابه
Astrocytes and Developmental Plasticity in Fragile X
A growing body of research indicates a pivotal role for astrocytes at the developing synapse. In particular, astrocytes are dynamically involved in governing synapse structure, function, and plasticity. In the postnatal brain, their appearance at synapses coincides with periods of developmental plasticity when neural circuits are refined and established. Alterations in the partnership between a...
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Fragile X mental retardation protein (FMRP) and its autosomal paralog FXR2P are selective neuronal RNA-binding proteins, and mice that lack either protein exhibit cognitive deficits. Although double-mutant mice display more severe learning deficits than single mutants, the molecular mechanism behind this remains unknown. In the present study, we discovered that FXR2P (also known as FXR2) is imp...
متن کاملSynaptic regulation of protein synthesis and the fragile X protein.
Protein synthesis occurs in neuronal dendrites, often near synapses. Polyribosomal aggregates often appear in dendritic spines, particularly during development. Polyribosomal aggregates in spines increase during experience-dependent synaptogenesis, e.g., in rats in a complex environment. Some protein synthesis appears to be regulated directly by synaptic activity. We use "synaptoneurosomes," a ...
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| Fragile X syndrome (FXS) is a developmental disorder resulting from trinucleoide repeat expansion in the 5’UTR of FMR1 gene. Cognitive deficiency and autistic features are among the common phenotypes of FXS. FMR1 gene codes for the protein FMRP, the absence of which leads to abnormal dendritic spine morphology and defective synaptic plasticity in animal models of fragile X syndrome. FMRP is a...
متن کاملDevelopmental expression of Xenopus fragile X mental retardation-1 gene.
Dysregulation of Fragile X mental retardation-1 (Fmr1) gene expression results in an inherited form of mental retardation known as the Fragile X syndrome (FXS). Fmr1 is a highly conserved gene with a broad yet distinctive expression pattern during vertebrate development. Here, we examined the expression pattern of Fmr1 during Xenopus embryonic development. Zygotic expression of Fmr1 began just ...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2010
ISSN: 1471-2202
DOI: 10.1186/1471-2202-11-132